Formulation And Evaluation of Herbal Suppositories Containing Guggul for The Treatment of Piles

Abstract

The aim of this research was to formulate and evaluate herbal suppositories containing guggul as a chief herbal drug for the treatment of piles. The suppositories were formulated using extracts of guggul, tridax procumbanas, and haritaki. guggul and haritaki are used as anti-inflammatory agents, and tridax procumbans is used as an antiseptic agent. Polyethylene glycol 4000 and beeswax are used as a suppository base. The formulated suppositories were evaluated for parameters including visual appearance (fissuring, pitting, fat blooming, exudation of active ingredient), length and width, weight variation, melting point, disintegration test, and in vitro anti-inflammatory activity by using the protein denaturation method and the protein inhibition method. The physical parameter was found to be within acceptable limit. The anti-inflammatory activity revealed the formulated suppositories has comparable anti-inflammatory activity as compared to standard drug diclofenac sodium (56.64 % vs 64.16%).